| Date | Location | Result | |
| 02/26/22 | Atlanta, GA - Woodruff PE Center | Rochester 70, Emory 55 | Box score |
| 02/20/22 | Rochester, NY - Louis Alexander Palestra | Rochester 68, Case Western Reserve 55 | Box score |
| 02/18/22 | Rochester, NY - Louis Alexander Palestra | Carnegie Mellon 66, Rochester 54 | Box score |
| 02/13/22 | St. Louis, MO - WU Field House | Washington-St. Louis 65, Rochester 48 | Box score |
| 02/11/22 | Chicago, IL - Ratner Athletics Center | Rochester 74, Chicago 68 | Box score |
| 02/06/22 | Waltham, MA - Red Auerbach Arena | Rochester 72, Brandeis 55 | Box score |
| 02/04/22 | Brooklyn, NY - Generoso Pope Complex | NYU 85, Rochester 63 | Box score |
| 01/30/22 | Rochester, NY - Louis Alexander Palestra | Brandeis 66, Rochester 59 | Box score |
| 01/28/22 | Rochester, NY - Louis Alexander Palestra | Rochester 57, NYU 53 | Box score |
| 01/23/22 | Cleveland, OH - Horsburgh Gymnasium | Rochester 75, Case Western Reserve 62 | Box score |
| 01/21/22 | Pittsburgh, PA - Weigand Gymnasium | Carnegie Mellon 63, Rochester 47 | Box score |
| 01/16/22 | Rochester, NY - Louis Alexander Palestra | Washington-St. Louis 78, Rochester 71 | Box score |
| 01/14/22 | Rochester, NY - Louis Alexander Palestra | Rochester 73, Chicago 60 | Box score |
| 01/08/22 | Rochester, NY - Louis Alexander Palestra | Rochester 71, Emory 66 (OT) | Box score |
| 01/04/22 | Henrietta, NY - Clark Gymnasium | Rochester 94, RIT 50 | Box score |
| 12/07/21 | Ithaca, NY - Ben Light Gymnasium | Rochester 64, Ithaca 62 | Box score |
| 12/04/21 | Keuka Park, NY - JMW Recreation Center | Rochester 97, Keuka 55 | Box score |
| 11/28/21 | Arlington, VA - Rose Bente Lee Center | Marymount (VA) 67, Rochester 50 | Box score |
| 11/23/21 | Rochester, NY - Louis Alexander Palestra | Rochester 82, William Smith 55 | Box score |
| 11/20/21 | Pittsford, NY - Manning & Napier Gym | St. John Fisher 56, Rochester 53 | Box score |
| 11/18/21 | Pittsford, NY - Manning & Napier Gym | Rochester 80, Nazareth 54 | Box score |
| 11/16/21 | Rochester, NY - Louis Alexander Palestra | SUNY Brockport 69, Rochester 65 | Box score |
| 11/13/21 | Rochester, NY - Louis Alexander Palestra | Rochester 74, Southern Va. 56 | Box score |
| 11/12/21 | Rochester, NY - Louis Alexander Palestra | Rochester 83, SUNY New Paltz 66 | Box score |
| 11/09/21 | Rochester, NY - Louis Alexander Palestra | Rochester 91, Buffalo State 55 | Box score |